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Table S3: Excluded studies and reason

406 FGF21 is recognized as a stress response factor that addresses mitochondrial dysfunction in cells

But when we look at the literature in patients with PCOS we see an interesting story, serum testosterone seems to decrease when GLP1 inhibitors are taken alone (10) and when they are taken with metformin there is an increase in SHBG (11,12.) This seems to me to again point to how complex the endocrine system is: we dont fully understand the interplay between insulin, sex steroid hormones, and SHBG

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10.1038/nprot.2008.211 Nat

References: Harris E, et al