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If A1c reduction is insufficient after adequate time at a given dose, escalation to the next tier is appropriate

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Mice were palpated twice weekly for 3 weeks, and tumor sizes were measured with electronic calipers until the majority of one of the experimental groups reached maximum allowable size, defined as a diameter of 1.5 cm measured in any direction

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Imaging was performed with a STELLARIS 5 Cryo laser scanning confocal microscope (Leica, Germany)

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Low capture genes with less than ten total counts summed across all samples were removed

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