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LepR is expressed in hypothalamic astrocytes [192, 193], and hypothalamic astrocytes participate in the mediation of leptin signaling [194, 195]
On average, participants in this study remained on the drug for approximately 13 months before discontinuation
Benefit-risk assessment of exenatide in the therapy of type 2 diabetes mellitus
Crit Rev Clin Lab Sci
Since the intervention components are combined as a package and evaluated together in these trials, this creates notable limitations when attempting to modify the interventions to make them more scalable, affordable, and efficient
