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For the scenario of "Currently available treatment with proven outcomes," research data suggests Semaglutide may be more relevant

The authors found the glucose infusion rate (GIR) during the clamp study decreased with OXM compared with OXMQ3E in wild-type mice, likely due to increased hepatic glucose output from GCGR agonism with OXM

This explains why gut-expressed receptors respond to the compound even before its absorbed systemically

The investigation specifically showed that these drugs did not increase the risk of any fractures, confirming their safety profile in clinical practice ( 4.6 Ophthalmological effects 4.6.1 Glaucoma GLP-1R agonists exhibit anti-inflammatory and neuroprotective properties, suggesting they could also be beneficial in neurodegenerative diseases ( A recent registry-based case-control study, summarized in Table 2 , involving 1,961 patients found that the use of GLP-1R agonists is linked to a lower risk of glaucoma (Sterling et al., 2021 (79)

( 10.1016/S2213-8587(1830024-X) [DOI] [PubMed] [Google Scholar] 106.Pratley R, Amod A, Hoff ST, Kadowaki T, Lingvay I, Nauck M, Pedersen KB, Saugstrup T, Meier JJ

The active ingredient in Trulicity is dulaglutide, and for Ozempic, it is semaglutide
