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Hormonal Changes and Metabolic Signaling Estrogen plays a meaningful role in how the body handles energy

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Hypothalamic Grb10 enhances leptin signalling and promotes weight loss

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Each step lasts four weeks: Weeks 1-4: 0.25 mg Weeks 5-8: 0.5 mg Weeks 9-12: 1.0 mg Weeks 13-16: 1.7 mg Week 17 onward: 2.4 mg The FDA-approved prescribing information states that if a patient does not tolerate a dose during titration, the dose escalation may be delayed for up to four additional weeks [11]

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