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A random effects model was selected to perform the meta-analyses, results were expressed as weighted mean differences for continuous outcomes and relative risks for dichotomous outcomes, both with 95% confidence intervals, and with I2 values and P values as markers of heterogeneity

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RR 0.51, P<0.001), cerebrovascular disease (RR 0.50, P<0.001), and heart failure (RR 0.55, P<0.001)
