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The broader systematic review of GLP-1 drugs in pain conditions [9] and the 2025 comprehensive review in the Journal of Headache and Pain [1] both conclude that the mechanistic case is plausible and interesting, but that human clinical trials with pain as the primary outcome are needed before we can make firm recommendations

In the STEP 13 clinical trials conducted between 2018 and 2020, semaglutide was shown to significantly reduce inflammatory markers

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doi: 10.1001/jama.2015.9676 10 DaviesM