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Goldman Sachs forecasts that the global weight-loss drug market will reach USD 114 billion by 2030, an upward revision of 13% from last years estimate

An emerging strategy to mitigate barriers related to NuSH therapy is microdosing, an off- label technique where lower or fractional doses are used to improve access, affordability, and/ or tolerability Microdosing GLP- 1RA and GIP/GLP- 1RA has been advertised by direct- to- consumer telehealth companies and on social media platforms and implemented in clinical practice without peer- reviewed, evidence- based guidance

Dozens of confusingly similar brands are flooding the market, leaving HCPs and pharmacies struggling to differentiate

However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis