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2022 JAMA Internal Medicine meta-analysis: pooling 76 randomised controlled trials, GLP-1 receptor agonist use was associated with a relative risk of 1.37 for biliary disease compared with placebo or other treatments

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However, it has traditionally been believed that T2D drugs are more efficacious for subjects with higher HbA1C, partly due to the relief of the stress from glucotoxicity [24], and that is what we observed as well

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