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Nevertheless, insofar as the physiological, postprandial GLP1 release from L cells is concerned, gutderived GLP1 might not reach the CNS at all, but primarily acts locally in a paracrine fashion, activating GLP1 receptors in the vicinity of the intestinal system (Richards et al., 2014)

however, growing evidence suggests that they may also provide benefits for other conditions, including PCOS ( 4 , 5 )

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For diarrhea management, psyllium is again the first choice