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7.4.4 Next-generation agonists The development of dual GLP-1/GIP receptor agonists (e.g., tirzepatide) and novel blood-brain barrier-penetrant formulations may offer superior neuroprotective efficacy by more potently engaging central receptors or providing a broader spectrum of action (Ghaleb et al., 2025)

Omeprazole and other PPIs are safe with GLP-1 medications

Understanding why helps set realistic expectations and troubleshoot if results are not appearing on the expected timeline

Below, we explain these concerns in detail and provide practical solutions

At Plan Medicare, we help beneficiaries understand their Medicare options, including Medicare Advantage, Medicare Supplement, and Part D prescription drug coverage