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Slower gastric emptying may alter absorption

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The most common side effects of tirzepatide are gastrointestinal, including nausea (12-30%), diarrhea (7-22%), vomiting (2-10%), constipation (5-17%), and abdominal pain (5-10%)

This approach helps support tolerability and allows your provider to safely adjust dosing over time based on your response

Injectable tirzepatide reaches peak blood concentrations faster than the oral form, which often means side effects appear slightly earlier but also resolve faster in many cases

avoid routine NSAID use if you are dehydrated or have kidney or stomach risks without a clinician's input