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But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators

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Learn about dermatological reactions with Ozempic, Wegovy, and Rybelsus, including injection site reactions, when to seek medical care, and management strategies for skin symptoms during GLP-1 treatment.

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