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Diabetes Care, 43 (2), 487-493

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47 In addition, despite high leptin production in response to overeating, leptin responsiveness becomes blunted in those with obesity and insulin resistance, such that high circulating leptin levels lose their impact on appetite and metabolism, resulting in a state described as leptin resistance

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For a single-concentration study or a series of replicates at the same dose, the format reduces handler variance considerably

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