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If you are dealing with this, it helps to know that these symptoms have a biological explanation, and that there are reasonable everyday steps that may ease them

Jamie Velazquez, PharmD

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and suicidality: a replication study using reports to the World Health Organization pharmacovigilance database (VigiBase )

Real-world data cited in the paper suggest roughly half of patients discontinue treatment within a year of starting it a rate far higher than the trials, with their closer supervision, capture

Future studies should prioritize early PsA populations, ideally using stratified designs that incorporate metabolic profiling, to fully elucidate the dual immunomodulatory and metabolic potential of GLP-1RAs in altering disease trajectory

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