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Heres commentary from Lily management: There's no doubt in my mind, Geoff in five years, as I said, we're going to have a lot more data and we're going to see these drugs as foundational medical treatment for many chronic diseases, and with outcomes to hard outcomes data that moves the cost curve in populations. And eventually the Venn diagram of seniors who have obesity or overweight and other conditions, diabetes, of course already we have access in many plans there, but we'll be adding to that pie

GI side effects like nausea or constipation affect about 30% of users initially, but resolve within 24 weeks for most people and can be managed with dose adjustment and dietary fiber

Participants (18 years) with inadequately controlled type 2 diabetes (HbA1c 80-100%) with metformin and with or without sulfonylurea were randomly assigned (1:1) by an interactive web-response system to 20 mg or 10 mg once-weekly semaglutide

Obesity contributes to renal damage through hemodynamic changes, including glomerular hyperfiltration and increased renal plasma flow, which over time lead to glomerular hypertrophy and focal segmental glomerulosclerosis (4)

For a more detailed take on statistical significance, please read this post by Dr

Monitor for nausea, appetite changes, and injection site reactions