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The tolerability profile is dominated by GI adverse events at higher rates than earlier-generation GLP-1s, with higher dropout at 12 mg than at 9 mg

Modifications in intestinal microbial structure compromise barrier integrity, facilitating bacterial product migration into the portal circulation

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Per Cleveland Clinic Pathology consultation, the liver parenchymal architecture was preserved
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Although body mass index was a strong predictor (AUC = 0.799), adding anti-GIP Ab levels modestly improved model performance (AUC = 0.819)
