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Personalized treatment strategies, guided by both efficacy and tolerability, are essential to optimize outcomes in this growing patient population
With proper nutrition and exercise, muscle loss is preventable
dose adjustments to those medicines may be required and should be discussed with a clinician
Rapid plateaus within 46 weeks may warrant provider review of dose adequacy, injection technique, or concurrent lifestyle factors
Knockout of MAGEL2 reduces leptin sensitivity and inhibits POMC neurons activity, causing disruption of hypothalamic feeding circuits, hyperphagia and obesity [163]
