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Hence metformin becomes the preferred drug with better outcomes

10.1038/s41569-021-00605-5 80 ShahS

Side Effects Profile All three medications share common side effects, primarily gastrointestinal: Nausea (usually temporary, worst in first few weeks) Diarrhea or constipation Abdominal discomfort Reduced appetite (this is the goal, but can feel uncomfortable initially) The higher dose of Wegovy may cause more pronounced side effects initially, while Saxendas daily dosing can offer more stable blood levels with potentially fewer ups and downs

Some practitioners start with semaglutide (more data) and switch to tirzepatide (broader mechanism) if response is insufficient

Most patients notice minimal appetite changes at this dose

* This statement has not been evaluated by the Food & Drug Administration