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Similarly, an analysis utilizing the UK Clinical Practice Research Datalink (CPRD) revealed that GLP-1 RAs were linked to an increased incidence of intestinal obstruction requiring hospitalization, compared to sodium-glucose cotransporter-2 (SGLT-2) inhibitors (1.9 vs

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doi: 10.1152/ajpendo.90222.2008

109,110 The proposed mechanism involves a decrease in endothelial cell oxidative stress

However, oral bioavailability is significantly lower than injectable, and absorption depends heavily on an empty stomach

Population-based cohort studies using real-world data have further supported these findings