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3 (8), a003947 (2011)

Although our data align with the notion that inhibiting NMDA receptor signalling in the hypothalamus decreases food intake and body weight 8,40 , earlier studies have demonstrated that NMDA receptor antagonism in the brainstem attenuates vagus-mediated meal-related satiety 6,7,42

Tirzepatide (weekly) is a dual GIP/GLP-1 agonist with potentially greater results

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Body composition can shift, hydration can fluctuate, and step-ups can pause weight loss without ending progress

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