what is safer tirzepatide or semaglutide vs. Semaglutide: You Should Know Tirzepatide vs. Ozempic: Comparing Diabetes

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The mean rate of eGFR decline was -1.4 per year in the combined tirzepatide groups and -3.6 per year in the insulin group (between-group difference 2.2 [95% CI 1.6 to 2.8]) with a greater benefit in participants with eGFR 500mg/dl the use of bile acid sequestrants is contraindicated (424)

Maintaining adequate hydration is paramount, particularly given semaglutide's gastrointestinal side effects

In the Phase 2 Retatrutide trial, dose-dependent increases in heart rate were observed, which peaked at around 24 weeks and declined thereafter

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