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Abstract Introduction Novel glucagon-like peptide-1 (GLP-1) receptor agonist oral semaglutide has demonstrated greater improvements in glycated hemoglobin (HbA1c) and body weight versus oral medications empagliflozin and sitagliptin, and injectable GLP-1 analog liraglutide, in the PIONEER clinical trial program

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Circadian disruption and an out of sync hormones Studies show that circadian (internal body clock) misalignment can increase ghrelin levels

Statistical analysis Data were analysed using an intention-to-treat approach, where all collected data from the participant would be included in the analysis, even if a participant did not complete the study