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That's part of the reason the weight loss is greater. But for patients who dont qualify for surgery or arent ready for it, GLP-1 drugs provide a new option

References CVS Caremark

Numerous regions of the brain express GLP-1 receptors which together synergistically impact food intake and reward-based behavior

doi: 10.1016/j.lfs.2020.117531

12 pounds per week (68 pounds per month) , though results depend on factors like adherence, activity level, and metabolism
Most people notice appetite changes within the first week, though significant weight loss typically emerges after 24 weeks of consistent therapy
