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Factors such as side effects, high out-of-pocket costs, injection fatigue and stigma around obesity treatment drive troves of patients some studies estimate roughly half or more to stop GLP-1s within a year and risk regaining the weight they lost

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One of the largest real-world analyses in T2DM More than 64,000 participants Evaluated a practical "everyday clinic" decision rather than an idealized RCT scenario Compared therapy intensification versus complete therapeutic switch Reflected real-world dose titration patterns and clinician behavior

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