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As shown in Figure 2, GLP-1RAs potentially increase focus on weight loss as a measure of self-worth, accentuating overvaluation of shape and weight, which is the core psychopathology of eating disorders

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The first GLP-1RAs will go off patent in the early 2020-ties and this will undoubtedly lower the price

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Gut microbiota composition (including Firmicutes , Bacteroidetes , Akkermansia , and Bifidobacterium ) influences host metabolism by producing short-chain fatty acids (SCFAs), generating secondary bile acids, modulating immune and inflammatory pathways, and stimulating GLP-1 secretion from intestinal L-cells

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Current Nutrition Reports, 14(1), 63

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Active Akt increased the protein levels and transactivation activity of Mash1,117 suggesting the potential function of the GLP-1-activated PI3K-Akt pathway

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While semaglutide does not directly cause leg cramps through its pharmacological mechanism, several indirect pathways related to its effects and the physiological changes during treatment may potentially contribute to muscle cramping in susceptible individuals

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