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The most commonly reported side effects during the first month are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, consistent with other GLP-1-containing therapies

Another key question is whether psychiatric effects are direct or secondary to metabolic improvements

Diabetes status: Type 2 diabetes, prediabetes, or none

The majority of patients were White (97%) and 51% were male

Constipation means contents are backing up in the large intestine, which creates additional fermentation opportunity and can increase gas production throughout the entire digestive tract

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