glp-1 substance use disorder Weight Loss Drugs May Also Curb Disorders GLP-1 addiction risk Linked to

B.KhuntiK.KosiborodM.ShestakovaM

The mechanism goes like this

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Research has unveiled the potential for GLP-1 receptor agonists to treat a growing range of psychiatric and neurological conditions

The GLP-1 RA and Its Relationship with Brain Insulin Resistance Brain IR can be defined as the failure of brain cells to respond to insulin, and the lack of response may be due to the downregulation of insulin receptors, an inability of insulin receptors to bind insulin, or faulty activation of the insulin signaling cascade.16 Insulin receptors are distributed throughout the brain, but have the highest concentration in the olfactory bulb, cerebral cortex, hypothalamus, hippocampus, and cerebellum.17 Insulin binds to the insulin receptor, phosphorylates the insulin receptor substrate (IRS), activates the phosphoinositide-3 kinase (PI3K) and mitogen-activated kinase (MAPK) pathways, and modifies the activity of several downstream effectors

The magnitude of the association was stronger for each outcome in per-protocol analyses (eTable 8 in Supplement 1)