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Two randomised trials in healthy subjects evaluated the effect of various dosing schedules (including different pre-dose and/or post-dose fasting times) on the steady-state pharmacokinetics of oral semaglutide
To investigate the impact of production methods on the stability and impurities of semaglutide drug substances and products and their potential impact on drug quality, efficacy, and safety RP-HPLC analysis was conducted using a C18 column with a mobile phase consisting of acetonitrile, isopropyl alcohol, water and 0.08 M ammonium phosphate [88]
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