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In head-to-head trials against semaglutide, the most potent available GLP-1 receptor agonist, tirzepatide demonstrated meaningfully greater improvements in both glycemic control and weight reduction

Tirzepatide versus insulin glargine as second-line or third-line therapy in type 2 diabetes in the Asia-Pacific region: The SURPASS-AP-Combo trial

Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once weekly Half-Life 5 days Route of Administration : Subcutaneous injection Dosing Frequency : Once weekly Half-Life : ~5 days Formulation : Lyophilized powder for reconstitution Formulation & Handling Store at 20C Protect from light and moisture Reconstitute with sterile water