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Effects of novel dual GIP and GLP-1 receptor agonist Tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes

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Neither drug is yet FDA approved, but ongoing clinical trials continue to show potential for future use in chronic weight management

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Specification of Target Trials Study Overview We compared semaglutide or tirzepatide with other antidiabetic medications for the associated risk of optic nerve and visual pathway disorders in patients with type 2 diabetes who had no prior diagnosis of any eye disorder (determined by the absence of International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ ICD-10 ] codes H00-H59, Diseases of the eye and adnexa, documented in EHRs) using a target trial emulation framework