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During intentional weight losswhether from calorie restriction or GLP-1 therapybile chemistry shifts and gallstone risk increases temporarily

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While this makes it less convenient for some people, it remains a proven and effective alternative when weekly injections are not suitable or available

Its advisable to aim for the minimal effective dose, starting low and gradually increasing if necessary

It functions as a dual agonist of both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors

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