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These effects collectively lower both fasting and postmeal glucose levels, with an average 24h glucose reduction of about 1 mmol/L [56, 57]

doi: 10.1016/j.cmet.2011.02.001 58 FlintARabenAAstrupAHolstJJ
As potency improved to below 100 nM in the absence of BETP, the impact of the PAM gradually diminished (Fig

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doi: 10.1016/j.molmet.2022.101638 87 GasbjergLSHelstedMMHartmannBSparre-UlrichAHVeedfaldSStensenSet al