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They operate through distinct neurological and metabolic pathways

The more meaningful question is not: Do patients regain weight after stopping GLP-1s? It is: How should we transition patients from pharmacologic support to long-term weight maintenance? Obesity is a chronic disease

New research indicates that maintaining meaningful weight loss after starting GLP-1-based therapies could play an important role in reducing the risk of multiple obesity-related diseases.

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Glucagon-like peptide-1 (GLP-1) is an incretin peptide hormone mainly secreted by enteroendocrine intestinal L-cells

Aims/hypothesis Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval