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Many weight loss methods, including GLP-1 medications like semaglutide and retatrutide , lead to unintended loss of lean mass

Such pathologic elevations in left-sided filling pressures and their effects on the pulmonary circulation are widely considered to be a principal cause of exercise intolerance in this population

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But preclinical studies suggest that they likely reflect the involvement of GLP-1 receptors in modulating the brains reward and aversive systems, they said

Archived from the original on 17 May 2012