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Despite demonstrating robust glycemic efficacy, both agents were eventually discontinued due to distinct tolerability and safety concerns, diverging in severity and clinical implications

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Fiorentino TV, Casiraghi F, Davalli AM, et al (2019) Exenatide regulates pancreatic islet integrity and insulin sensitivity in the nonhuman primate baboon Papio hamadryas

If we rely on a one-size-fits-all approach, we risk harming patients by promoting muscle loss or triggering nutritional deficiencies

Interestingly, patients who receive GLP-1 receptor analogs, and who develop antibodies against the drug, tend to have more injection site reactions, despite the fact that they experience similar rates and types of adverse events to those experienced by patients who do not develop antibodies [48, 105, 106, 109, 110]

The Bigger Picture If youve ever been close to addictionwhether its your own or someone elsesyou know how insidious it is

Supplementary Information The online version of this article ( contains peer-reviewed but unedited supplementary material