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Cushing syndrome , whether from excess cortisol production or chronic steroid use, causes characteristic central weight gain

There is at least preclinical evidence that GLP-1RAs and SGLT-2is may modulate the composition and activity of gut microorganisms to produce metabolites such as bile acids, SCFAs, and endotoxins

Providers evaluate cardiovascular health through detailed history-taking and may order risk-based assessments such as electrocardiograms, blood pressure monitoring, and assessment of heart rate

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