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Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)

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Additionally, the study looked at cardiovascular outcomes as a pre-specified secondary analysis which included a four-point composite endpoint of cardiovascular death, myocardial infarction, stroke, and hospitalization for unstable angina

[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Zhuo S., Bai M., Wang Z., Chen L., Li Z., Zhu X., Chen J., Ye X., Guo C., Chen Y

Together, they play a critical role in glucose homeostasis by stimulating insulin secretion following a meal