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Their rapid breakdown in the human body also makes them a relatively safe option for use

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See a doctor if nausea is intense, persists for days, or is accompanied by vomiting, dehydration, or weight loss

For example, in the study we cited where berberine went up against metformin, 35% of subjects had significant gastrointestinal upset when taking the 1,500 mg/day dose (three capsules worth)