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The effect of dulaglutide on a liver fat (D-LIFT) trial included 64 patients with T2DM and MRI-PDFF 6.0% at baseline [51]

In real-world practice, especially in the resource-limited settings, these findings may help support more nuanced, individualized decisions

In a paradoxical fashion, postprandial hyperglucagonemia a common finding in T2DM contributes to glucose excursions in the fed state

Lowers glucagon: Glucagon is a hormone that raises blood sugar

Second, the reduction in fat mass, particularly visceral fat, removes a major source of inflammatory cytokine production