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Although the postprandial secretion of the active GLP-1(736) amide was shown to be impaired in type 2 diabetic patients ( 29 ) , the insulinotropic activity of GLP-1, but not GIP, was preserved in patients with mild type 2 diabetes ( 30 )

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Semaglutide is the established global standard of care with balanced GLP-1 receptor signaling

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JAMA (2011) 305:50