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Lancet Diabetes Endocrinol (2017) 5:35566

Another meta-analysis, including a total of 1,101 adult participants with type 2 diabetes or prediabetes, demonstrated that intermittent fasting (IF) led to significant reductions in body weight (4.56 kg), body mass index (1.99 kg/m 2 ), HbA1c (0.81%), fasting glucose (0.36 mmol/L), total cholesterol (0.31 mmol/L), and triglycerides (0.14 mmol/L), without exerting a significant impact on fat mass, insulin levels, LDL, HDL, or blood pressure compared to control groups (133)

Vidotti, J

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These cytokines also contribute to IR through mechanisms including inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) pathway, while also promoting glucocorticoid resistance and HPA axis hyperactivity [80]