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While hypothyroidism is characterized by an underactive thyroid gland and reduced thyroid hormone production, hyperthyroidism is marked by an overactive thyroid gland and excess thyroid hormone production

This hexadecapeptide has shown remarkable effects on fat metabolism by upregulating lipolysis and inhibiting lipogenesis

Dose adjustments are typically based on response, tolerance, and overall treatment goals

Some GLP-1 agonists also target an additional set of receptors called glucose-dependent insulinotropic polypeptide (GIP) receptors

It has FDA approval, a well-characterized safety profile, and proven efficacy for its specific target

What happens after potential approval Assuming retatrutide eventually receives FDA approval, several practical questions arise for the research and clinical communities