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doi: 10.3389/fimmu.2025.1703964 Received 12 September 2025 Accepted 27 October 2025 Published 10 November 2025 Volume 16 - 2025 Edited by Marina De Bernard, University of Padua, Italy Reviewed by Attinder Chadha, University of California, San Francisco, United States Ruoxi Zhang, University of Texas Southwestern Medical Center, United States Updates Copyright 2025 Wen, Liang, Zhao, Xuan, Meng, Liu, Wang, He, Zhou, Tao and Wang

[DOI] [PubMed] [Google Scholar] Gromada J, Rorsman P

These medications work by mimicking incretin hormones, which stimulate insulin secretion, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

If you're considering stopping GLP-1 therapy or exploring alternatives , several evidence-based approaches can help maintain metabolic improvements and manage weight or blood glucose levels effectively

The cornerstone approach involves optimising the rate of weight loss to allow physiological adaptation