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In early trials, average weight loss reached 25% by week 4 and up to 24.2% by 48 weeks (12mg dose)
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Clinicians are aware of this and may monitor for gallbladder symptoms if patients lose weight very fast
Next, we assessed how HIF-1 levels are modulated by the activity of PI3K/mTOR axis in this setting
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In many studies, these agents have also been associated with reductions in blood pressure, although the extent to which this effect depends directly on weight loss has remained less clearly defined
