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When starting a GLP-1 RA it is important to consider adjustment of background therapies to avoid treatment emergent hypoglycemia and/or unnecessary therapeutic duplication

If you have a medical question, ask your doctor, pharmacist, or other qualified healthcare professional

One of the most common concerns patients experience is digestive discomfort, especially constipation

Keywords: Glucagon, Glucagon-like peptide-1 receptor agonist, Glucose-dependent insulinotropic peptide receptor, Incretin, Obesity, Type 2 diabetes mellitus Introduction Type 2 diabetes mellitus (T2DM) and obesity are becoming more and more common worldwide, a phenomenon which greatly increases morbidity and mortality from conditions like cancer and heart disease, among many others [1]

The STEP-HFpEF-DM trial confirmed the benefits of once-weekly semaglutide also in obese patients affected by type 2 diabetes

While not a one-size-fits-all solution, GLP-1RAs could offer new hope for those struggling with fatigue, MCAS, and other chronic conditions