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They've been restricting calories for months

The drug is a once-a-week injection that combines two hormones, GLP-1 and GIP, which work in combination to stimulate insulin secretion and reduce appetite

With both medications being so effective, the logical next question is: can you combine them

Effect of exenatide, sitagliptin, or glimepiride on beta-cell secretory capacity in early type 2 diabetes

Both medications show similar early appetite suppression within 1-2 weeks, but tirzepatide (a GLP-1/GIP dual agonist) often produces slightly faster cumulative weight loss in clinical trialsaveraging 21% versus 15% body weight reduction over comparable periods

Jody Dushay, an assistant professor of medicine at Harvard Medical School and an attending physician in endocrinology at Beth Israel Deaconess Medical Center, who prescribes weight-loss medications