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Abbreviations BBB Bloodbrain barrier CNS Central Nervous System GFAP Glial fibrillary acidic protein GLP-1R Glucagon-like peptide-1 receptor HFD Highfat diet IB4 Biotinylated isolectin B4 Iba-1 Ionized calciumbinding adaptor molecule-1 ND Normolipid diet NVU Neurovascular unit SAL Saline solution SEMA Semaglutide Author contributions VE wrote the main manuscript

After activation by full agonists such as GLP-1, GLP-1R couples with Gs, activates adenylate cyclase (AC), and causes the accumulation of cAMP

Many patients do their weekly compounded semaglutide injection at home after the team teaches them the technique, and the needle is small

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But beyond its impact on blood sugar control, GLP-1 supports weight management through multiple beneficial mechanisms

What should I do if I get constipated on semaglutide