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Heres how we are thinking about this evolving opportunity as equity investors, and what well be monitoring as GLP-1s impact extends in many new directions

GLP-1 response to Oral glucose is reduced in Prediabetes, screen-detected type 2 diabetes, and obesity and influenced by sex: the ADDITION-PRO study

The observations that GLP-1R signaling in cells is essential for control of insulin secretion, together with data suggesting that exendin(9-39) may attenuate insulin secretion through reduction of cell cyclic AMP (97), has supported investigational use of exendin(9-39) for the treatment of severe hyperinsulinemic hypoglycemia

Dual agonists that target both GLP-1 and GIP receptors provide a more comprehensive metabolic effect than single-receptor medications

Is Semaglutide GLP-1 suitable for individuals with a BMI over 40

Both obesity and diabetes are major concerns, in health systems and for societies, said Yael Wolff-Sagy, an epidemiologist at Clalit Health Services and first author of the study