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The included studies on exendin-4 exposure were all performed in mouse models ( In rat, mouse and rabbit models without systemic inflammation, the other GLP1-receptor agonists (except exendin-4), dose dependently caused reduced fetal weight and/or growth, retardation of ossification, irregular ossification, and/or skeletal variants such as wavy ribs ( Table 1 )
Viral Infections and Incretin Pathways: What the Literature Hints Though limited, some evidence supports this hypothesis: A 2018 study in Cell Reports found that microbial and viral byproducts can stimulate GLP-1 secretion via Toll-like receptor (TLR) activation on L-cells
A phase II, randomized, double-blinded, placebo-controlled trial of liraglutide in Parkinsons disease [preprint]
West, J
Its possible that the study wasnt long enough to show all the beneficial effects over time, Chen says
You're technically supposed to be on [GLP-1s] once you start forever
